M. Glushkov is the creator of the theory of digital automata, the theory and practice of computer design, the world's unique computer design automation system "PROJECT", the theory of programming and algorithmic algebra systems, and artificial intelligence systems. Under his leadership, for the first time in the world, supercomputers with a new multiprocessor macroconveyor architecture (MIMD architecture according to the modern classification) were created, as well as computers "Dnepr", "Kiev", "Promin", MIR-1, MIR-2, MIR-3 and others.
For the first time in the world, V. M. Glushkov developed a holistic project of the digital state and digital economy OGAS - a project of a Nationwide automated system for collecting and processing information for accounting, planning and managing the national economy of the USSR. V. M. Glushkov - the main ideologist and one of the main creators of the industry of management information systems in the USSR, under his scientific leadership a number of management information systems of enterprises were created and large industrial management information systems (MIS), MIS "Moscow" as well as management information system of the Armed Forces of the USSR. He was the scientific director of the interdepartmental committee and the Board of Directors of the main institutes of defense industries for management, economics and informatics.
M. Glushkov developed artificial intelligence systems such as "eye-hand", "reading automaton", "self-organizing system", decision support systems, and mathematical proof automation systems.
M. Glushkov is the author of more than 800 scientific publications.